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Extended Publication List

Benjamin Steyer, Qian Bu, Evan Cory, Keer Jiang, Stella Duong, Divya Sinha, Stephanie Steltzer, David Gamm, Qiang Chang, and Krishanu Saha. (2018) Scarless genome editing of human pluripotent stem cells via transient puromycin selection. Link | PDF

Jared Carlson-Stevermer, Amr Abdeen, Lucy Kohlenberg, Kaivalya Molugu, Madelyn Goedland, Meng Lou and Krishanu Saha. (2017) Assembly of CRISPR ribonucleoproteins with biotinylated oligonucleotides via an RNA aptamer for precise gene editing. Nature Communications. 8, 1711

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Amr Abdeen, Krishanu Saha (2017) Manufacturing cell therapies using engineered biomaterials. Trends in Biotechnology. 35, 971-982.

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Nicole Piscopo, Katie Mueller, Amritava Das, Peiman Hematti, William Murphy, Sean Palecek, Christian Capitini, Krishanu Saha (2017) Bioengineering solutions for manufacturing challenges in CAR T cells. Biotechnology Journal.

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Jared Carlson-Stevermer, Ty Harkness, Ryan Prestil, Stephanie Seymour, Gavin Knight, Randolph Ashton, Krishanu Saha(2017) Micropatterned substrates to promote and dissect reprogramming of human somatic cells. in review. Link

Benjamin Steyer, Jared Carlson-Stevermer, Nicolas Angenent-Mari, Andrew Khalil, Ty Harkness, Krishanu Saha (2015) High content analysis platform for optimization of lipid mediated CRISPR-Cas9 delivery strategies in human cells. Acta Biomaterialia. 34, 143-158.

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Jared Carlson-Stevermer, Madelyn Goedland, Benjamin Steyer, Arezoo Muvaghar, Meng Lou, Lucille Kohlenberg, Ryan Prestil, Krishanu Saha. (2016) High-Content Analysis of CRISPR-Cas9 Gene-Edited Human Embryonic Stem Cells. Stem Cell Reports. 12(1) 109-120

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Ty Harkness, Jason McNulty, Ryan Prestil, Stephanie Seymour, Tyler Klann, Michael Murrell, Randolph Ashton, Krishanu Saha (2015) “High-content imaging with micropatterned multiwell plates reveals influence of cell geometry and cytoskeleton on chromatin dynamics”. Biotechnology Journal. 10 1555-1567

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Travis Cordie, Ty Harkness, Xin Jing, Jared Carlson-Stevermer, Hao-Yang Mi, Lih-Sheng Turng, and Krishanu Saha (2014) “Nanofibrous Electrospun Polymers for Reprogramming Human Cells”. Cellular and Molecular Bioengineering. 7(3) 379-393

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Jonathan W. Armond, Krishanu Saha, Anas A. Rana, Chris J. Oates, Rudolf Jaenisch, Mario Nicodemi & Sach Mukherjee (2014) “A stochastic model dissects cell states in biological transition processes” Scientific Reports . 4, 3692.

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Virendra Gajbhiye, Leah Escalante, Guojun Chen, Alex Laperle, Qifeng Zheng, Benjamin Steyer, Shaoqin Gong and Krishanu Saha (2014) “Drug-loaded nanoparticles induce gene expression in human pluripotent stem cell derivatives” Nanoscale . 6, 521-531.

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Saha K.*, Mei Y.*, Reisterer C.M., Pyzocha N., Yang J., Muffat J., Alexander M.R., Langer R., Anderson D.G. and Jaenisch R. (2011) “Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions.” Proceedings of the National Academy of Sciences of the USA. 108(46), 18714-9. [*equal contribution]

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Hanna J., Saha K., and Jaenisch R. (2010) “Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues.” Cell. 143(4) 508-525.

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Saha K., Kim J., Irwin E., Yoon J., Momin F., Trujillo V., Schaffer D.V., Healy K.E., and R.C. Hayward (2010) “Surface creasing instability of soft polyacrylamide cell culture substrates.” Biophysical Journal. 99(12) L94-L96.

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Mei Y.*, Saha K.*, Bogatyrev S., Yang J., Hook A.L., Kalcioglu Z.I., Cho S.W., Mitalipova M., Pyzocha N., Rojas F., van Vliet K.J., Davies M.C., Alexander M.R., Langer R.S., Jaenisch R., and Anderson D.G. (2010) “Combinatorial Development of Biomaterials for Clonal Growth of Human Pluripotent Stem Cells.” Nature Materials. 9, 768-778. [*equal contribution]

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Hanna J., Cheng A.W., Saha K., Kim J., Lengner C.J., Soldner F., Cassady J.P., Muffat J., Carey B.W., and Jaenisch R. (2010) “Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs.” Proceedings of the National Academy of Sciences of the USA. 107(20), 9222-9227.

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Saha K. and R. Jaenisch (2009) “Technical challenges in using human induced pluripotent stem cells to model disease.” Cell Stem Cell. 5, 584-595.

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Hanna J.*, Saha K.*, Pando B., van Zon J., Lengner C.J., Creyghton M.P., van Oudenaarden A., and Jaenisch R. (2009) “Direct cell reprogramming is a stochastic process amenable to acceleration.” Nature. 462, 595-601. [*equal contribution]

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Carey B.W., Markoulaki S., Hanna J., Saha K., Gao Q., Mitalipova M., and Jaenisch R. (2009) “Reprogramming of murine and human somatic cells using a single polycistronic vector.” Proceedings of the National Academy of Sciences of the USA. 106(1), 157-162.

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Saha K., Keung A., Irwin E.F., Li Y., Schaffer D.V. and Healy K.E. (2008) “Substrate modulus directs neural stem cell behavior.” Biophysical Journal. 95(9), 4426-4438.

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Irwin E.F., Saha K., Rosenbluth M., Gamble, L.J., Castner D.G., and Healy K.E. (2008) “Modulus-dependent macrophage adhesion and behavior.” Journal of Biomaterial Science: Polymer Edition. 19(10), 1363-1382.

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Wall S.T., Saha K., Ashton R.S., Kam K.R., Schaffer D.V. and Healy K.E. (2008) “Multivalency of Sonic hedgehog conjugated to linear polymer chains modulates protein potency.” Bioconjugate Chemistry. 19(4), 806–812.

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Saha K.*, Pollock J.F.*, Schaffer D.V., and K.E. Healy. (2007) “Designing synthetic materials to control stem cell phenotype.” Current Opinion in Chemical Biology. 11(4), 381-7. [*equal contribution]

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Saha K., Irwin E.F., Kozhukh J., Healy K.E., and D.V. Schaffer (2007) “Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior.” Journal of Biomedical Materials Research: Part A. 81A:1.

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Saha K. and D.V. Schaffer (2006) “Signaling dynamics in Sonic hedgehog tissue patterning.” Development. 133, 889-900.

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Saha K., Bender F., Rasmusson A., and E. Gizeli (2003) “Probing the viscoelasticity of protein layers with acoustic waveguide devices.” Langmuir. 19(4), 1304-1311.

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Saha K., Bender F., and E. Gizeli (2003) “Comparative study of IgG binding to bacterial proteins G and A: Non-equilibrium kinetic binding constant determination with the acoustic waveguide device.” Analytical Chemistry. 75(4), 835-842.

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Gizeli, E., Bender, F., Rasmusson A., Saha K., Josse F., and R. Cernosek (2003) “Sensitivity of the acoustic waveguide biosensor to protein binding as a function of the device geometry.” Biosensors and Bioelectronics. 18(11), 1399-406.

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Science & Technology Studies / Science Policy

Krishanu Saha. “Navigating the Manufacturing Process and Ensuring the Quality of Regenerative Medicine Therapies.” (2017) Forum on Regenerative Medicine.

Hurlbut, J. Benjamin, Krishanu Saha, and Sheila Jasanoff. “CRISPR Democracy: Gene Editing and the Need for Inclusive Deliberation.” (2015) Issues in Science and Technology 32, no. 1. Spring Issue.

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Saha, K.(2014) “Stem Cells, IPS Cells”. Discoveries in Modern Science: Exploration, Invention, Technology, J. Trefil, ed. (Farmington Hills, MI: Macmillan Reference USA), pp. 1068–1074.

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Saha, K., and Hogle, L.F. (2014). “Allying with Donors to Link Health and Medical Information with Stem Cell Lines Can Advance Disease Modeling while Enhancing Data Access”. Cell Stem Cell 14, 559–560.

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Pfotenhauer, S.M., Jones C.F., Saha K., and S. Jasanoff. (2012) “Learning from Fukushima.” Issues in Science and Technology. Spring Issue.

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Saha K. and J.B. Hurlbut(2011) “Treat donors as partners in biobank research.” Nature. 478, 312-313.

Link | Alternate link: Click here and then on red PDF button in new window | Press

Discussed further in Nature and The Scientist.

Mathews D.J.H., Graff G.D., Saha K., Winickoff D.E. (2011) “Access To Stem Cells And Data: Persons, Property Rights, And Scientific Progress.” Science. 331, 725-727.

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Saha K. and J.B. Hurlbut(2011) “Disease modeling using pluripotent stem cells: making sense of disease from bench to bedside.” Swiss Medical Weekly. 141.

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Winickoff D.W.*, Saha K.*, and Graff G.* (2009) “Opening Life Sciences Research and Development: Integrative Management of Data, IP and Ethics in Stem Cells” Yale Journal of Health Policy, Law and Ethics. 9(1), 52-127. [*equal contribution]

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